Seminars

Yasunori Hayashi

Lundi 16 juillet 2018 à 11h30
Department of Pharmacology, Kyoto University Graduate School of Medicine, Japan
"The mechanism converting a transient Ca2+signaling into persistent biochemical signaling during LTP"
Invité par : Jean-Christophe Poncer

 Long-term synaptic plasticity requires a mechanism that converts short Ca2+ pulses into persistent biochemical signaling to support the changes in the function and structure of synapses over long period of time. Here, we present a positive feedback loop, formed by a "reciprocally activating kinase-effector complex" (RAKEC) in dendritic spines, enabling the persistence and confinement of the molecular memory. We found that stimulation of a single spine causes the rapid formation of a RAKEC consists of a kinase CaMKII and its substrate a RacGEF TIAM1, which can stably promote actin-polymerization through Rac1, thereby maintaining the structure of the spine over a long period of time during LTP. This is achieved by a pseudo-autoinhibitory domain found within TIAM1, homologous to the autoinhibitory domain of CaMKII. RAKEC can store biochemical information in small subcellular compartments, thus potentially serving as a general mechanism for the production of prolonged and compartmentalized signaling.

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